Thoughts of the family tree may not be uppermost in the mind of a person suffering from a slipped disc, but those spinal1 discs provide a window into our evolutionary2 past. They are remnants of the first vertebrate skeleton, whose origins now appear to be older than had been assumed. Scientists at the European Molecular3 Biology Laboratory in Heidelberg, Germany, have found that, unexpectedly, this skeleton most likely evolved from a muscle. The study, carried out in collaboration4 with researchers at the Howard Hughes Medical Institute in Janelia Farm, USA, is published today in Science.Humans are part of a group of animals called chordates, whose defining feature is a rod of cartilage that runs lengthwise along the middle of their body, under their spinal chord. This structure, called the notochord, was the first vertebrate skeleton. It is present in human embryos5, and is replaced with the backbone6 as we develop, with the cartilage reduced to those tell-tale discs. Since starfish, sea urchins7 and related animals have no such structure, scientists assumed the notochord had emerged in a relatively8 recent ancestor, after our branch of the evolutionary tree split away from the starfish branch.People simply havent been looking beyond our direct relatives, but that means you could be fooled, if the structure appeared earlier and that single group lost it, says Detlev Arendt from EMBL, who led the study. And in fact, when we looked at a broader range of animals, this is what we found.Antonella Lauri and Thibaut Brunet, both in Arendts lab, identified the genetic9 signature of the notochord -- the combination of genes10 that have to be turned on for a healthy notochord to form. When they found that the larva of the marine11 worm Platynereis has a group of cells with that same genetic signature, the scientists teamed up with Philipp Kellers group at Janelia Farm to use state-of-the-art microscopy to follow those cells as the larva developed. They found that the cells form a muscle that runs along the animals midline, precisely12 where the notochord would be if the worm were a chordate. The researchers named this muscle the axochord, as it runs along the animals axis13. A combination of experimental work and combing through the scientific literature revealed that most of the animal groups that sit between Platynereis and chordates on the evolutionary tree also have a similar, muscle-based structure in the same position.The scientists reason that such a structure probably first emerged in an ancient ancestor, before all these different animal groups branched out on their separate evolutionary paths. Such a scenario14 would also explain why the lancelet amphioxus, a primitive15 chordate, has a notochord with both cartilage and muscle. Rather than having acquired the muscle independently, amphioxus could be a living record of the transition from muscle-based midline to cartilaginous notochord.The shift from muscle to cartilage could have come about because a stiffened16 central rod would make swimming more efficient, the scientists postulate17.
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1 spinal adj.针的，尖刺的，尖刺状突起的；adj.脊骨的，脊髓的 参考例句： After three days in Japan,the spinal column becomes extraordinarily flexible.在日本三天，就已经使脊椎骨变得富有弹性了。 Your spinal column is made up of 24 movable vertebrae.你的脊柱由24个活动的脊椎骨构成。
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